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Bulletin of the Multinational Center of Quality of Life Research

Bulletin of the Multinational Center of Quality of Life Research





D. A. Fedorenko, T. I. Ionova

Prognostic value of quality of life data in patients with malignant lymphomas undergoing autologous hematopoietic stem cell transplantation

The goal of this study was to evaluate quality of life (QoL) in patients with malignant lymphomas before autologous hematopoietic stem cell transplantation (HSCT) and to analyze the prognostic value of pretreatment QoL.

A total of 124 lymphoma patients were enrolled in the study (non-Hodgkin's lymphomas - 45 patients, Hodgkin's lymphoma – 79 patients). The patients were 19–65 years old (mean age - 34), male/female – 42,7 %/57,3 % (53/71). QoL was evaluated using RAND SF-36. To compare the QoL parameters with population norms we formed a group of 204 healthy people, male/female=99/105, mean age – 37. Lymphoma patients before HSCT had worse QoL in comparison with population norms. At least 1/3 of patients showed severe or critical decrease of QoL. 5-year overall survival in patients with severe and critical QoL impairment was 58,6% in comparison with 68% for patients with no or mild QoL impairment (p=0,02).

According to these results, it is possible to consider patients with no or mild QoL impairment as having favorable prognosis after HSCT; and patients with severe or critical QoL impairment – as having unfavorable prognosis. Thus, pretreatment QoL may be used as a significant prognostic factor for HSCT outcomes assessment.




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