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Bulletin of the Multinational Center of Quality of Life Research

Bulletin of the Multinational Center of Quality of Life Research





T.I. Ionova, V.I. Odin, T.P. Nikitina, K.A. Kurbatova, N.E. Shablovskaya

Quality of life in patients with type 2 diabetes receiving oral antidiabetic treatment

Comparative analysis of quality of life in patients with type 2 diabetes receiving different oral antidiabetic treatment. Two groups of patients were involved in the study: the first group (n=83) received metformin in combination with sulfonylureas (M+SU) and the second group (n=111) received metformin in combination with vildagliptin (M+V). It was shown that quality of life of patients receiving M+V was better than in the group receiving M+SU (p<0.05).

The quality of life data in the majority of M+V patients did not differ from population norms, while in the second group only 52% of patients approached satisfactory quality of life level. Additionally, after the switch from metformin monotherapy to M+V, a significant improvement of quality of life was identified; at the same time there were no significant changes in quality of life parameters of patients switched to M+SU therapy.

The reduction of HbA1c level after the switch from monotherapy to combined therapy in both groups was similar (by 0.8%). In terms of patient-reported outcomes M+V therapy is more effective than M+SU therapy. Implementation of patient-reported outcomes may be of value for decision making in management of diabetes patients.




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