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Bulletin of the Multinational Center of Quality of Life Research

Bulletin of the Multinational Center of Quality of Life Research





T. I. Ionova, V. I. Odin, T. P. Nikitina, K. A. Kurbatova, N. E. Shablovskaya

Hypoglycemia problems in patients with type 2 diabetes receiving traditional and innovative oral hypoglycemic therapy

Frequency of hypoglycemia and problems related with hypoglycemia in patients with type 2 diabetes receiving traditional and innovative oral hypoglycemic therapy were studied using patient-reported outcomes. Two groups of patients were included in the analysis: the first group (n=83) received metformin in combination with sulfonylurea (traditional treatment approach) and the second group (n=111) received metformin in combination with vildagliptin (innovative treatment approach).

The number of hypoglycemia episodes, as well as hypoglycemia concern, anxiety and other problems associated with this condition, were less expressed in patients receiving metformin+vildagliptin. When patients were switched from metformin monotherapy to metformin+vildagliptin the frequency of hypoglycemia episodes reduced significantly; in the group of patients switched to metformin+sulfonylurea hypoglycemia episodes happened more often and hypoglycemia burden increased.

The reduction of HbA1c level in both groups was similar (by 0.8%). In terms of patient-reported outcomes metformin+vildagliptin therapy is more effective in terms of tolerability than metformin+sulfonylurea therapy. Implementation of patient-reported outcomes approach and the use of Hypoglycemia Perspectives Questionnaire may contribute to comprehensive management of diabetes patients.




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