About us   Contacts   Links   Information in Russian 
Research programms
Journal
Bulletin of the Multinational Center for Quality of Life Research

Bulletin of the Multinational Center of Quality of Life Research





E.В V. Zhukovskaya1, T.В P. Nikitina2,3, N.В M. Porfirieva3, S.В M. Chechelnitskaya1, A.В F. Karelin1

Quality of life and associated factors in children and adolescents with acute lymphoblastic leukemia and lymphomas during rehabilitation


1В DMITRY ROGACHEV NATIONAL MEDICAL RESEARCH CENTER OF PEDIATRIC HEMATOLOGY, ONCOLOGY AND IMMUNOLOGY OF THE MINISTRY OF HEALTH OF RUSSIAN FEDERATION, MOSCOW

2В SAINT-PETERSBURG STATE UNIVERSITY HOSPITAL, SAINT-PETERSBURG

3В MULTINATIONAL CENTER FOR QUALITY OF LIFE RESEARCH, SAINT-PETERSBURG

Currently, it is worthwhile to develop effective rehabilitation programs for children cancer survivors. A key criterion for assessing the rehabilitation effect is the patient's quality of life (QoL). The aim of this study was to investigate the dynamics of QoL in pediatric and adolescent patients with acute lymphoblastic leukemia (ALL) and lymphomas during rehabilitation and to analyze the factors that influence QoL before and after rehabilitation. The data were analyzed for 209 children with ALL and 81 children with lymphomas who underwent rehabilitation after completing antitumor treatment on the basis of the Medical and Rehabilitation Scientific Center В«Russkoe PoleВ», taking into account the influence of various factors. It has been shown that according to the reports of children with ALL, such factors as gender, age at the beginning of therapy, the duration of remission and vitamin D levels influence the Total Scale score of PedsQL questionnaire before rehabilitation, and the protocol of anti-tumor treatment is also important. In patients with lymphomas, no significant effect on the score of Total scale of any of the studied factors or their combinations has been established. Improvement of QoL was demonstrated after rehabilitation in both groups, taking into account gender, age at the beginning of therapy, duration of remission, metabolic homeostasis, as well as baseline QoL according to children self-reports and their parents proxy-reports, to a greater extent expressed in the ALL group. Metabolic homeostasis had a significant impact on QoL in patients with ALL before and after rehabilitation. In children with lymphomas, no factors were identified that had impact on QoL before and after rehabilitation. The results can be useful in the development of measures to improve the rehabilitation effect in children after the completion of antitumor therapy, taking into account significant factors, including, among other things, indicators of metabolic homeostasis.





© Создание сайтов

Последнее обновление (last update): 17-07-2024









Яндекс цитирования